Sulfadiazine sodium jẹ oogun aporo ajẹsara sulfonamide ti n ṣiṣẹ alabọde ti o ni awọn ipa antibacterial lori ọpọlọpọ awọn kokoro arun Giramu-rere ati Giramu-odi. O ni awọn ipa antibacterial lori Staphylococcus aureus ti kii ṣe enzyme, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella, Neisseria gonorrhoeae, Neisseria meningitidis, ati aarun ayọkẹlẹ Haemophilus. Ni afikun, o tun ṣiṣẹ lodi si Chlamydia trachomatis, Nocardia asteroides, Plasmodium, ati Toxoplasma in vitro. Iṣẹ ṣiṣe antibacterial ti ọja yii jẹ kanna bi ti sulfamethoxazole. Sibẹsibẹ, ni awọn ọdun aipẹ, resistance kokoro si ọja yii ti pọ si, paapaa Streptococcus, Neisseria, ati Enterobacteriaceae.