Sulfamethazine
Alaye ipilẹ:
Orukọ ọja: Sulfamethazine
Orukọ: sulfadimethylpyrimidine
Ilana kemikali: C12H14N4O2S
Ilana igbekalẹ:
Iwọn molikula: 278.33
CAS nọmba wiwọle: 57-68-1
EINECS nọmba titẹsi: 200-346-4
Ti ara ati kemikali-ini
iwuwo: 1.392g/cm3
Oju Iyọ: 197°C
Ojutu farabale: 526.2ºC
Aaye filasi: 272.1ºC
Irisi: funfun kirisita lulú
Solubility: fere insoluble ninu omi, insoluble ni ether, awọn iṣọrọ tiotuka ni dilute acid tabi dilute alkali ojutu
Sulfadiazine jẹ apakokoro sulfanilamide ti o ni iru irisi antibacterial ti o jọra si sulfadiazine. O ni awọn ipa antibacterial lori awọn kokoro arun enterobacteriaceae gẹgẹbi awọn Staphylococcus aureus ti kii-zymogenic, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella, ati bẹbẹ lọ Neisseria gonorrhoea, Neisseria meningitidis ati Haisseria meningitidis. Sibẹsibẹ, resistance kokoro si ọja naa pọ si, paapaa streptococcus, Neisseria ati awọn kokoro arun Enterobacteriaceae. Sulfonamides jẹ awọn aṣoju bacteriostatic ti o gbooro, ti o jọra ni eto si p-aminobenzoic acid (PABA), eyiti o le ṣiṣẹ ni idije lori dihydrofolate synthetase ninu awọn kokoro arun, nitorinaa idilọwọ PABA lati ṣee lo bi ohun elo aise lati ṣe iṣelọpọ folate ti o nilo nipasẹ awọn kokoro arun ati idinku iye ti tetrahydrofolate ti nṣiṣe lọwọ iṣelọpọ agbara. Igbẹhin jẹ nkan pataki fun iṣelọpọ ti awọn purines, thymidine nucleosides ati deoxyribonucleic acid (DNA), nitorina o ṣe idiwọ idagbasoke ati ẹda ti awọn kokoro arun.
O jẹ lilo ni pataki fun awọn akoran kekere ti o fa nipasẹ awọn kokoro arun ti o ni imọlara, gẹgẹbi ikolu ito kekere ti o rọrun nla, media otitis nla ati akoran àsopọ asọ ti awọ ara.
